pentobarbital will lessen the level or result of artemether/lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration with sturdy CYP3A4 inducers can lead to lessened serum concentrations and loss of antimalarial efficacy
pentobarbital will reduce the level or outcome of eletriptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Comment: Barbiturates may possibly raise adverse effects, which includes respiratory melancholy, made by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates maximize metabolism and decrease blood concentrations of TCAs.
pentobarbital will reduce the level or influence of pitolisant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Pitolisant exposure is lowered by fifty% if coadministered with powerful CYP3A4 inducers.
pentobarbital will lower the level or influence of fosphenytoin by influencing hepatic enzyme CYP2C9/ten metabolism. Use Warning/Watch.
Contraindicated (one)pentobarbital will lower the level or result of dienogest/estradiol valerate by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Girls shouldn't pick estradiol valerate/dienogest as their contraceptive though making use of robust CYP3A4 inducers resulting from opportunity lessen in contraceptive efficacy.
Both increases toxicity of one other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory despair, coma, and death may possibly outcome if coadministered. Reserve concomitant prescribing of these drugs in people for whom other treatment selections are inadequate. Restrict dosages and durations to your minimal necessary. Keep track of carefully read more for signs of respiratory melancholy and sedation.
pentobarbital will lower the level or outcome of methadone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Selections regarding the timing of any elective processes demanding anesthesia ought to just take into account the main advantages of the procedure weighed in opposition to the probable pitfalls
pentobarbital will decrease the extent or impact of aprepitant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will decrease the level or influence of duvelisib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration with a strong CYP3A inducer decreases duvelisib region underneath the curve (AUC), which may lessen duvelisib efficacy.
Keep track of Carefully (three)pentobarbital will minimize the level or impact of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Robust or reasonable CYP3A4 inducers could enhance level of diazepam elimination; consequently, efficacy of diazepam could possibly be diminished.
pentobarbital will reduce the level or outcome of rolapitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Long-phrase coadministration of sturdy CYP3A4 inducers with rolapitant may perhaps substantially minimize rolapitant efficacy.
pentobarbital will lessen the extent or influence of eltrombopag by impacting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Observe.